Nitrosation in the environment: can it occur?
نویسنده
چکیده
coumarin dissolved in acetone or dichloromethane (1), might nevertheless be expected. A nonvolatile test chemical would still be retained on surfaces exterior to the embryo after evaporation of the solvent. Subsequent imbibition by the seeds in water would then introduce the test chemical into the embryo just as readily as if the test chemical had originally been in aqueous solution. LARRY L. TRIPLErr ALAN H. HABER Biology Division, Oak Ridge National Laboratory, Post Office Box Y, Oak Ridge, Tennessee 37830
منابع مشابه
Relevance of nitrosamines to human cancer.
It is now about three decades since the hepatocarcinogenic effect of N-nitrosodimethylamine (NDMA)* was demonstrated in rats (1) and the suggestion was made that N-nitrosamines can be formed following nitrosation of various amines (2). Direct proof that such nitrosation reactions can occur was provided by Ender et al. (3) who identified NDMA in nitrite preserved fish-meal, and by Sander and Sei...
متن کاملOxygen-Linked S-Nitrosation in Fish Myoglobins: A Cysteine-Specific Tertiary Allosteric Effect
The discovery that cysteine (Cys) S-nitrosation of trout myoglobin (Mb) increases heme O2 affinity has revealed a novel allosteric effect that may promote hypoxia-induced nitric oxide (NO) delivery in the trout heart and improve myocardial efficiency. To better understand this allosteric effect, we investigated the functional effects and structural origin of S-nitrosation in selected fish Mbs d...
متن کاملReactivity of amino acids in nitrosation reactions and its relation to the alkylating potential of their products.
Nitrosation reactions of amino acids with an -NH(2) group [namely, six alpha-amino acids (glycine, alanine, alpha-aminobutyric acid, alpha-aminoisobutyric acid, valine, and norvaline); two beta-amino acids (beta-alanine and beta-aminobutyric acid), and one gamma-amino acid (gamma-aminobutyric acid)] were studied. Nitrosation was carried out in aqueous acid media, mimicking the conditions of the...
متن کاملIn vivo nitrosation of amidopyrine in humans: use of 'ethanol effect' for biological monitoring of N-nitrosodimethylamine in urine.
Under normal conditions a possible N-nitrosodimethylamine formation in vivo cannot directly be monitored in urine due to high metabolic conversion rate (greater than 99.9%). Own experiments showed an increased excretion rate (up to 2.4%) if ethanol was administered simultaneously. This model was used for monitoring experiments with respect to in vivo formation of N-nitrosodimethylamine. Amidopy...
متن کاملFormation of S-nitrosothiols via direct nucleophilic nitrosation of thiols by peroxynitrite with elimination of hydrogen peroxide.
Peroxynitrite (ONOO-), a potent oxidant formed by reaction of nitric oxide (NO.) with superoxide anion, can activate guanylyl cyclase and is able to induce vasodilation or inhibit platelet aggregation and leukocyte adhesion, via thiol-dependent formation of NO. Reaction of ONOO- with thiols is thought to proceed through formation of a S-nitrothiol (thionitrate; RSNO2) intermediate and yields lo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Science
دوره 179 4068 شماره
صفحات -
تاریخ انتشار 1973